CATH Classification

Domain Context

CATH Clusters

Superfamily FMN-linked oxidoreductases
Functional Family Heptaprenylglyceryl phosphate synthase

Enzyme Information

2.5.1.41
Phosphoglycerol geranylgeranyltransferase.
based on mapping to UniProt O26652
Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.
-!- Catalyzes the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria. -!- It catalyzes the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate. -!- The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.42 and EC 2.7.7.67, which lead to the formation of CDP-unsaturated archaeol. -!- The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.

UniProtKB Entries (1)

O26652
GGGPS_METTH
Methanothermobacter thermautotrophicus str. Delta H
Geranylgeranylglyceryl phosphate synthase

PDB Structure

PDB 5NEZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
crystal structure of variants from MtGGGPS
Sterner, R., Babinger, P., Linde, M., Rajendran, C.
To Be Published