1 keywords

CATH Domain 5mn2B02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.40 Immunoglobulin-like
Homologous Superfamily 2.60.40.10 Immunoglobulins

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family High affinity immunoglobulin gamma Fc receptor I

Enzyme Information

UniProtKB Entries (1)

P08637
FCG3A_HUMAN
Homo sapiens
Low affinity immunoglobulin gamma Fc region receptor III-A

PDB Structure

PDB 5MN2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Robinson, J.I., Baxter, E.W., Owen, R.L., Thomsen, M., Tomlinson, D.C., Waterhouse, M.P., Win, S.J., Nettleship, J.E., Tiede, C., Foster, R.J., Owens, R.J., Fishwick, C.W.G., Harris, S.A., Goldman, A., McPherson, M.J., Morgan, A.W.
Proc. Natl. Acad. Sci. U.S.A.