CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Low molecular weight phosphotyrosine protein

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P24666
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.2
Acid phosphatase.
based on mapping to UniProt P24666
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Wide specificity. -!- Also catalyzes transphosphorylations.

UniProtKB Entries (1)

P24666
PPAC_HUMAN
Homo sapiens
Low molecular weight phosphotyrosine protein phosphatase

PDB Structure

PDB 5KQM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism.
He, R., Wang, J., Yu, Z.H., Zhang, R.Y., Liu, S., Wu, L., Zhang, Z.Y.
J.Med.Chem.