CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Multidrug resistance protein 1A

Enzyme Information

7.6.2.2
ABC-type xenobiotic transporter.
based on mapping to UniProt P21447
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).
-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- Does not undergo phosphorylation during the transport process. -!- The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. -!- Several distinct enzymes may be present in a single eukaryotic cell. -!- Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1). -!- Formerly EC 3.6.3.44.

UniProtKB Entries (1)

P21447
MDR1A_MOUSE
Mus musculus
Multidrug resistance protein 1A

PDB Structure

PDB 5KOY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
Esser, L., Zhou, F., Pluchino, K.M., Shiloach, J., Ma, J., Tang, W.K., Gutierrez, C., Zhang, A., Shukla, S., Madigan, J.P., Zhou, T., Kwong, P.D., Ambudkar, S.V., Gottesman, M.M., Xia, D.
J. Biol. Chem.