CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Low molecular weight phosphotyrosine protein

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P24666
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.2
Acid phosphatase.
based on mapping to UniProt P24666
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Wide specificity. -!- Also catalyzes transphosphorylations.

UniProtKB Entries (1)

P24666
PPAC_HUMAN
Homo sapiens
Low molecular weight phosphotyrosine protein phosphatase

PDB Structure

PDB 5JNS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stanford, S.M., Aleshin, A.E., Zhang, V., Ardecky, R.J., Hedrick, M.P., Zou, J., Ganji, S.R., Bliss, M.R., Yamamoto, F., Bobkov, A.A., Kiselar, J., Liu, Y., Cadwell, G.W., Khare, S., Yu, J., Barquilla, A., Chung, T.D.Y., Mustelin, T., Schenk, S., Bankston, L.A., Liddington, R.C., Pinkerton, A.B., Bottini, N.
Nat. Chem. Biol.