CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Pancreatic alpha-amylase

Enzyme Information

3.2.1.1
Alpha-amylase.
based on mapping to UniProt P04746
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
-!- Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. -!- The term 'alpha' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolyzed.

UniProtKB Entries (1)

P04746
AMYP_HUMAN
Homo sapiens
Pancreatic alpha-amylase

PDB Structure

PDB 5EMY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase.
Caner, S., Zhang, X., Jiang, J., Chen, H.M., Nguyen, N.T., Overkleeft, H., Brayer, G.D., Withers, S.G.
Febs Lett.