CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent RNA helicase DDX3X

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt O00571
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O00571
DDX3X_HUMAN
Homo sapiens
ATP-dependent RNA helicase DDX3X

PDB Structure

PDB 5E7I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
Floor, S.N., Condon, K.J., Sharma, D., Jankowsky, E., Doudna, J.A.
J.Biol.Chem.