CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Probable ATP-dependent RNA helicase DDX58

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt O95786
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O95786
DDX58_HUMAN
Homo sapiens
Probable ATP-dependent RNA helicase DDX58

PDB Structure

PDB 5E3H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Jiang, F., Ramanathan, A., Miller, M.T., Tang, G.Q., Gale, M., Patel, S.S., Marcotrigiano, J.
Nature