CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamyl-tRNA reductase, N-terminal domain
Functional Family Glutamyl-tRNA reductase

Enzyme Information

1.2.1.70
Glutamyl-tRNA reductase.
based on mapping to UniProt P42804
L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH.
-!- Forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants. -!- However, in the alpha-proteobacteria EC 2.3.1.37 is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. -!- This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. -!- Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.

UniProtKB Entries (1)

Q940U6
FLU_ARATH
Arabidopsis thaliana
Protein FLUORESCENT IN BLUE LIGHT, chloroplastic

PDB Structure

PDB 5CHE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein
Fang, Y., Zhao, S., Zhang, F., Zhao, A., Zhang, W., Zhang, M., Liu, L.
Sci Rep