CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Triosephosphate isomerase |
Enzyme Information
| 5.3.1.1 |
Triose-phosphate isomerase.
based on mapping to UniProt P60174
D-glyceraldehyde 3-phosphate = glycerone phosphate.
|
| 4.2.3.3 |
Methylglyoxal synthase.
based on mapping to UniProt P60174
Glycerone phosphate = methylglyoxal + phosphate.
-!- Does not act on D-glyceraldehyde 3-phosphate. -!- Formerly EC 4.2.99.11.
|
UniProtKB Entries (1)
| P60174 |
TPIS_HUMAN
Homo sapiens
Triosephosphate isomerase
|
PDB Structure
| PDB | 4ZVJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.
Biochim. Biophys. Acta
|