CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Low molecular weight phosphotyrosine protein

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P24666
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.2
Acid phosphatase.
based on mapping to UniProt P24666
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Wide specificity. -!- Also catalyzes transphosphorylations.

UniProtKB Entries (1)

P24666
PPAC_HUMAN
Homo sapiens
Low molecular weight phosphotyrosine protein phosphatase

PDB Structure

PDB 4Z99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Fonseca, E.M., Trivella, D.B., Scorsato, V., Dias, M.P., Bazzo, N.L., Mandapati, K.R., de Oliveira, F.L., Ferreira-Halder, C.V., Pilli, R.A., Miranda, P.C., Aparicio, R.
Bioorg.Med.Chem.