CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt A7WYM2
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

A7WYM2
KTHY_STAA1
Staphylococcus aureus subsp. aureus Mu3
Thymidylate kinase

PDB Structure

PDB 4XWA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A highly potent antibacterial inhibitor of Gram-positive bacterial thymidylate kinase (TMK): SAR of piperidinyl thymines at position C5 and L1
Guler, S.Y., Martinez-Botella, G., Breen, J., Kawatkar, S., Loch, J., Olivier, N.B., Wang, H., Keating, T., Otterson, L.
Bioorg Med Chem Lett