CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21802
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21802
FGFR2_HUMAN
Homo sapiens
Fibroblast growth factor receptor 2

PDB Structure

PDB 4WV1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Yin, Y., Djakovic, S., Marsters, S., Tien, J., Peng, J., Tremayne, J., Lee, G., Neve, R.M., Wu, Y., Merchant, M., Ashkenazi, A., Carter, P.J.
Mol.Cancer Ther.