CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.4.2.12
Nicotinamide phosphoribosyltransferase.
based on mapping to UniProt P43490
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

UniProtKB Entries (1)

P43490
NAMPT_HUMAN
Homo sapiens
Nicotinamide phosphoribosyltransferase

PDB Structure

PDB 4WQ6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Zak, M., Liederer, B.M., Sampath, D., Yuen, P.W., Bair, K.W., Baumeister, T., Buckmelter, A.J., Clodfelter, K.H., Cheng, E., Crocker, L., Fu, B., Han, B., Li, G., Ho, Y.C., Lin, J., Liu, X., Ly, J., O'Brien, T., Reynolds, D.J., Skelton, N., Smith, C.C., Tay, S., Wang, W., Wang, Z., Xiao, Y., Zhang, L., Zhao, G., Zheng, X., Dragovich, P.S.
Bioorg.Med.Chem.Lett.