CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Aldo-keto reductase family 1 member C3

Enzyme Information

1.1.1.188
Prostaglandin-F synthase.
based on mapping to UniProt P42330
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2). -!- Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
1.1.1.112
Indanol dehydrogenase.
based on mapping to UniProt P42330
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
-!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
1.3.1.20
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P42330
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.239
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
based on mapping to UniProt P42330
Testosterone + NAD(+) = androstenedione + NADH.
-!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.
1.1.1.357
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P42330
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
1.1.1.64
Testosterone 17-beta-dehydrogenase (NADP(+)).
based on mapping to UniProt P42330
Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH.
-!- Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
1.-.-.-
Oxidoreductases.
based on mapping to UniProt P42330

UniProtKB Entries (1)

P42330
AK1C3_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C3

PDB Structure

PDB 4WDT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of complexes of type 5 17 beta-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding.
Amano, Y., Yamaguchi, T., Niimi, T., Sakashita, H.
Acta Crystallogr.,Sect.D