CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.1.2.51
2-dehydro-3-deoxy-D-gluconate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.
4.1.2.14
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
4.1.2.21
2-dehydro-3-deoxy-6-phosphogalactonate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme catalyzes the last reaction in a D-galactose degradation pathway. -!- Cf. EC 4.1.2.55.
4.1.2.-
Aldehyde-lyases.
based on mapping to UniProt Q6KZI8

UniProtKB Entries (1)

Q6KZI8
KDGA_PICTO
Picrophilus torridus DSM 9790
2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase

PDB Structure

PDB 4UXD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate.
Zaitsev, V., Johnsen, U., Reher, M., Ortjohann, M., Taylor, G.L., Danson, M.J., Schonheit, P., Crennell, S.J.
Biochemistry