CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P9WKE1
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P9WKE1
KTHY_MYCTU
Mycobacterium tuberculosis H37Rv
Thymidylate kinase

PDB Structure

PDB 4UNS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors.
Naik, M., Raichurkar, A., Bandodkar, B.S., Varun, B.V., Bhat, S., Kalkhambkar, R., Murugan, K., Menon, R., Bhat, J., Paul, B., Iyer, H., Hussein, S., Tucker, J.A., Vogtherr, M., Embrey, K.J., Mcmiken, H., Prasad, S., Gill, A., Ugarkar, B.G., Venkatraman, J., Read, J., Panda, M.
J.Med.Chem.