CATH Domain 4s3cA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.20	Dihydropteroate synthase-like

Domain Context

CATH Clusters

Superfamily	Dihydropteroate synthase-like
Functional Family

Enzyme Information

1.17.7.3

(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).

based on mapping to UniProt Q5SLI8

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.

-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).

UniProtKB Entries (1)

Q5SLI8

ISPG_THET8

Thermus thermophilus HB8

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

PDB Structure

PDB	4S3C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E., Groll, M. J.Mol.Biol.