CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Tyrosine-protein kinase receptor UFO

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P30530
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P30530
UFO_HUMAN
Homo sapiens
Tyrosine-protein kinase receptor UFO

PDB Structure

PDB 4RA0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Kariolis, M.S., Miao, Y.R., Jones, D.S., Kapur, S., Mathews, I.I., Giaccia, A.J., Cochran, J.R.
Nat.Chem.Biol.