CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.40
Functional Family Chromodomain-helicase-DNA-binding protein 2 isoform 1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt O14646
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (2)

O14646
CHD1_HUMAN
Homo sapiens
Chromodomain-helicase-DNA-binding protein 1
Q38SQ2
NS1_I83A8
Influenza A virus (A/Hong Kong/5/1983(H3N2))
Non-structural protein 1

PDB Structure

PDB 4O42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Qin, S., Liu, Y., Tempel, W., Eram, M.S., Bian, C., Liu, K., Senisterra, G., Crombet, L., Vedadi, M., Min, J.
Nat Commun