CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family KRAS proto-oncogene, GTPase

Enzyme Information

UniProtKB Entries (1)

P01112
RASH_HUMAN
Homo sapiens
GTPase HRas

PDB Structure

PDB 4NYJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Burns, M.C., Sun, Q., Daniels, R.N., Camper, D., Kennedy, J.P., Phan, J., Olejniczak, E.T., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W.
Proc.Natl.Acad.Sci.USA