CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

Enzyme Information

1.17.7.3
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
based on mapping to UniProt Q81LV7
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.
-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).

UniProtKB Entries (1)

Q81LV7
ISPG_BACAN
Bacillus anthracis
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

PDB Structure

PDB 4MWA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
1.85 Angstrom Crystal Structure of GCPE Protein from Bacillus anthracis.
Minasov, G., Wawrzak, Z., Brunzelle, J.S., Xu, X., Cui, H., Maltseva, N., Bishop, B., Kwon, K., Savchenko, A., Joachimiak, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
TO BE PUBLISHED