CATH Classification

Domain Context

CATH Clusters

Superfamily FMN-linked oxidoreductases
Functional Family Heptaprenylglyceryl phosphate synthase

Enzyme Information

2.5.1.41
Phosphoglycerol geranylgeranyltransferase.
based on mapping to UniProt O26652
Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.
-!- Catalyzes the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria. -!- It catalyzes the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate. -!- The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.42 and EC 2.7.7.67, which lead to the formation of CDP-unsaturated archaeol. -!- The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.

UniProtKB Entries (1)

O26652
GGGPS_METTH
Methanothermobacter thermautotrophicus str. Delta H
Geranylgeranylglyceryl phosphate synthase

PDB Structure

PDB 4MM1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Peterhoff, D., Beer, B., Rajendran, C., Kumpula, E.P., Kapetaniou, E., Guldan, H., Wierenga, R.K., Sterner, R., Babinger, P.
Mol.Microbiol.