CATH Classification

Domain Context

CATH Clusters

Superfamily EAL domain
Functional Family Cyclic di-GMP phosphodiesterase yahA

Enzyme Information

3.1.4.52
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P21514
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.

UniProtKB Entries (1)

P21514
PDEL_ECOLI
Escherichia coli K-12
Cyclic di-GMP phosphodiesterase PdeL

PDB Structure

PDB 4LJ3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP.
Sundriyal, A., Massa, C., Samoray, D., Zehender, F., Sharpe, T., Jenal, U., Schirmer, T.
J.Biol.Chem.