CATH Domain 4liqE05

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Macrophage colony-stimulating factor 1 receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P07333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07333

CSF1R_HUMAN

Homo sapiens

Macrophage colony-stimulating factor 1 receptor

PDB Structure

PDB	4LIQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy Ries, C.H., Cannarile, M.A., Hoves, S., Benz, J., Wartha, K., Runza, V., Rey-Giraud, F., Pradel, L.P., Feuerhake, F., Klaman, I., Jones, T., Jucknischke, U., Scheiblich, S., Kaluza, K., Gorr, I.H., Walz, A., Abiraj, K., Cassier, P.A., Sica, A., Gomez-Roca, C., de Visser, K.E., Italiano, A., Le Tourneau, C., Delord, J.P., Levitsky, H., Blay, J.Y., Ruttinger, D. Cancer Cell