CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.210
Functional Family 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Enzyme Information

2.1.1.14
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt P82610
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

P82610
METE_CANAL
Candida albicans SC5314
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

PDB Structure

PDB 4L64
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of a fungal methionine synthase with substrates and inhibitors.
Ubhi, D., Kago, G., Monzingo, A.F., Robertus, J.D.
J.Mol.Biol.