CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Deoxycytidine kinase

Enzyme Information

2.7.1.74
Deoxycytidine kinase.
based on mapping to UniProt P27707
NTP + deoxycytidine = NDP + dCMP.
-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

UniProtKB Entries (1)

P27707
DCK_HUMAN
Homo sapiens
Deoxycytidine kinase

PDB Structure

PDB 4L5B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
Murphy, J.M., Armijo, A.L., Nomme, J., Lee, C.H., Smith, Q.A., Li, Z., Campbell, D.O., Liao, H.I., Nathanson, D.A., Austin, W.R., Lee, J.T., Darvish, R., Wei, L., Wang, J., Su, Y., Damoiseaux, R., Sadeghi, S., Phelps, M.E., Herschman, H.R., Czernin, J., Alexandrova, A.N., Jung, M.E., Lavie, A., Radu, C.G.
J.Med.Chem.