CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family Ubiquitin thioesterase OTU1

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P43558
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (2)

P55072
TERA_HUMAN
Homo sapiens
Transitional endoplasmic reticulum ATPase
P43558
OTU1_YEAST
Saccharomyces cerevisiae S288C
Ubiquitin thioesterase OTU1

PDB Structure

PDB 4KDL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
Kim, S.J., Cho, J., Song, E.J., Kim, S.J., Kim, H.M., Lee, K.E., Suh, S.W., Kim, E.E.
J.Biol.Chem.