CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Aldo-keto reductase family 1 member C3

Enzyme Information

1.3.1.20
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P52895
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.357
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P52895
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
1.-.-.-
Oxidoreductases.
based on mapping to UniProt P52895

UniProtKB Entries (1)

P52895
AK1C2_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C2

PDB Structure

PDB 4JQ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of NSAID selectivity for the aldo-keto reductase 1C family
Yosaatmadja, Y., Flanagan, J.U., Squire, C.J.
To be Published