CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.3.2.10
Imidazole glycerol-phosphate synthase.
based on mapping to UniProt Q9X0C6
5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho- beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1- (5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1- (imidazol-4-yl)glycerol 3-phosphate + L-glutamate.
-!- The enzyme is involved in histidine biosynthesis, as well as purine nucleotide biosynthesis. -!- The enzymes from archaea and bacteria are heterodimeric. -!- A glutaminase component (cf. EC 3.5.1.2) produces an ammonia molecule that is transferred by a 25 A tunnel to a cyclase component, which adds it to the imidazole ring, leading to lysis of the molecule and cyclization of one of the products. -!- The glutminase subunit is only active within the dimeric complex. -!- In fungi and plants the two subunits are combined into a single polypeptide.

UniProtKB Entries (1)

Q9X0C6
HIS6_THEMA
Thermotoga maritima MSB8
Imidazole glycerol phosphate synthase subunit HisF

PDB Structure

PDB 4J9J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Establishing catalytic activity on an artificial ( beta alpha )8-barrel protein designed from identical half-barrels.
Sperl, J.M., Rohweder, B., Rajendran, C., Sterner, R.
Febs Lett.