CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidine kinase

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P03176
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118, and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P03176
KITH_HHV11
Herpes simplex virus (type 1 / strain 17)
Thymidine kinase

PDB Structure

PDB 4IVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer
Pernot, L., Novakovic, I., Perozzo, R., Raic-Malic, S., Scapozza, L.
To be Published