CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P48736
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB 4HLE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
Staben, S.T., Blaquiere, N., Tsui, V., Kolesnikov, A., Do, S., Bradley, E.K., Dotson, J., Goldsmith, R., Heffron, T.P., Lesnick, J., Lewis, C., Murray, J., Nonomiya, J., Olivero, A.G., Pang, J., Rouge, L., Salphati, L., Wei, B., Wiesmann, C., Wu, P.
Bioorg.Med.Chem.Lett.