CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P65249
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P65249
KTHY_STAAN
Staphylococcus aureus subsp. aureus N315
Thymidylate kinase

PDB Structure

PDB 4HEJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK).
Martinez-Botella, G., Breen, J.N., Duffy, J.E., Dumas, J., Geng, B., Gowers, I.K., Green, O.M., Guler, S., Hentemann, M.F., Hernandez-Juan, F.A., Joseph-McCarthy, D., Kawatkar, S., Larsen, N.A., Lazari, O., Loch, J.T., Macritchie, J.A., McKenzie, A.R., Newman, J.V., Olivier, N.B., Otterson, L.G., Owens, A.P., Read, J., Sheppard, D.W., Keating, T.A.
J.Med.Chem.