CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family |
Enzyme Information
| 1.1.1.358 |
2-dehydropantolactone reductase.
based on mapping to UniProt Q76L36
(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
-!- The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B(5)). -!- This entry covers enzymes whose stereo specificity for NADP(+) is not known (cf. EC 1.1.1.168 and EC 1.1.1.214).
|
| 1.1.1.168 |
2-dehydropantolactone reductase (Re-specific).
based on mapping to UniProt Q76L36
(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
-!- The enzyme from Saccharomyces cerevisiae differs from that from Escherichia coli (EC 1.1.1.214), which is specific for the Si-face of NADP, and in receptor requirements from EC 1.1.99.26.
|
UniProtKB Entries (1)
| Q76L36 |
CPRC2_CANPA
Candida parapsilosis
NADPH-dependent conjugated polyketone reductase C2
|
PDB Structure
| PDB | 4H8N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding
Appl.Microbiol.Biotechnol.
|