CATH Classification

Domain Context

CATH Clusters

Superfamily Metal-dependent hydrolases
Functional Family Parathion hydrolase

Enzyme Information

3.1.8.1
Aryldialkylphosphatase.
based on mapping to UniProt P0A434
An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
-!- Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. -!- Inhibited by chelating agents. -!- Previously regarded as identical with EC 3.1.1.2.

UniProtKB Entries (1)

P0A434
OPD_BREDI
Brevundimonas diminuta
Parathion hydrolase

PDB Structure

PDB 4GY1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
Tokuriki, N., Jackson, C.J., Afriat-Jurnou, L., Wyganowski, K.T., Tang, R., Tawfik, D.S.
Nat Commun