CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol (PI) phosphodiesterase
Functional Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt Q01970
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P21279
GNAQ_MOUSE
Mus musculus
Guanine nucleotide-binding protein G(q) subunit alpha
Q01970
PLCB3_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

PDB Structure

PDB 4GNK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
Lyon, A.M., Dutta, S., Boguth, C.A., Skiniotis, G., Tesmer, J.J.
Nat.Struct.Mol.Biol.