CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P48736
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB 4DK5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Smith, A.L., D'Angelo, N.D., Bo, Y.Y., Booker, S.K., Cee, V.J., Herberich, B., Hong, F.T., Jackson, C.L., Lanman, B.A., Liu, L., Nishimura, N., Pettus, L.H., Reed, A.B., Tadesse, S., Tamayo, N.A., Wurz, R.P., Yang, K., Andrews, K.L., Whittington, D.A., McCarter, J.D., Miguel, T.S., Zalameda, L., Jiang, J., Subramanian, R., Mullady, E.L., Caenepeel, S., Freeman, D.J., Wang, L., Zhang, N., Wu, T., Hughes, P.E., Norman, M.H.
J.Med.Chem.