CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Fructose-bisphosphate aldolase Fba

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P9WQA3
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P9WQA3
ALF_MYCTU
Mycobacterium tuberculosis H37Rv
Fructose-bisphosphate aldolase

PDB Structure

PDB 4DEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
Pegan, S.D., Rukseree, K., Capodagli, G.C., Baker, E.A., Krasnykh, O., Franzblau, S.G., Mesecar, A.D.
Biochemistry