CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Vitamin B12 import ATP-binding protein BtuD

Enzyme Information

7.6.2.8
ABC-type vitamin B12 transporter.
based on mapping to UniProt P06611
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) = ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1).
-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- Does not undergo phosphorylation during the transport process. -!- A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives. -!- Formerly EC 3.6.3.33.

UniProtKB Entries (1)

P06609
BTUC_ECOLI
Escherichia coli K-12
Vitamin B12 import system permease protein BtuC

PDB Structure

PDB 4DBL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF.
Korkhov, V.M., Mireku, S.A., Hvorup, R.N., Locher, K.P.
Febs Lett.