CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family

Enzyme Information

6.3.2.37
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase.
based on mapping to UniProt Q9WY79
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + D-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-N(epsilon)-D-lysine.
-!- Involved in the synthesis of cell-wall peptidoglycan. -!- The D-lysine is attached to the peptide chain at the N(6) position. -!- The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7. -!- Formerly EC 6.3.2.n1.
6.3.2.7
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
based on mapping to UniProt Q9WY79
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.

UniProtKB Entries (1)

Q9WY79
MURE_THEMA
Thermotoga maritima MSB8
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase

PDB Structure

PDB 4BUB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mreb and Murg as Scaffolds for the Cytoplasmic Steps of Peptidoglycan Biosynthesis
Favini-Stabile, S., Contreras-Martel, C., Thielens, N., Dessen, A.
Environ.Microbiol.