CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family Xylose isomerase

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P24300
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P24300
XYLA_STRRU
Streptomyces rubiginosus
Xylose isomerase

PDB Structure

PDB 4A8I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protein Crystallization and Microgravity: Glucose Isomerase Crystals Grown During the Pcdf-Protein Mission
Decanniere, K., Patino-Lopez, L.-D., Sleutel, M., Evrard, C., Van De Weerdt, C., Haumont, E., Gavira, J.A., Otalora, F., Maes, D.
To be Published