CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family probable ATP-dependent RNA helicase DDX17

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P17844
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P17844
DDX5_HUMAN
Homo sapiens
Probable ATP-dependent RNA helicase DDX5

PDB Structure

PDB 4A4D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Variable N-Terminal Region of Ddx5 Contains Structural Elements and Auto-Inhibits its Interaction with Ns5B of Hepatitis C Virus.
Dutta, S., Gupta, G., Choi, Y.W., Kotaka, M., Fielding, B.C., Song, J., Tan, Y.J.
Biochem.J.