CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

1.3.98.1
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q4D3W2
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

Q4D3W2
PYRD_TRYCC
Trypanosoma cruzi strain CL Brener
Dihydroorotate dehydrogenase (fumarate)

PDB Structure

PDB 3W2M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-183.
Inaoka, D.K., Iida, M., Tabuchi, T., Lee, N., Matsuoka, S., Shiba, T., Sakamoto, K., Suzuki, S., Balogun, E.O., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K.
To be Published