CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt Q9HZN8
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

Q9HZN8
KTHY_PSEAE
Pseudomonas aeruginosa PAO1
Thymidylate kinase

PDB Structure

PDB 3UWO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
Choi, J.Y., Plummer, M.S., Starr, J., Desbonnet, C.R., Soutter, H., Chang, J., Miller, J.R., Dillman, K., Miller, A.A., Roush, W.R.
J.Med.Chem.