CATH Domain 3uwkA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt Q9HZN8

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_PSEAE

Pseudomonas aeruginosa PAO1

Thymidylate kinase

PDB Structure

PDB	3UWK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. Choi, J.Y., Plummer, M.S., Starr, J., Desbonnet, C.R., Soutter, H., Chang, J., Miller, J.R., Dillman, K., Miller, A.A., Roush, W.R. J.Med.Chem.