CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Adenylate kinase 1

Enzyme Information

2.7.4.14
UMP/CMP kinase.
based on mapping to UniProt P20425
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
-!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. -!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22. -!- Formerly EC 2.7.4.5.

UniProtKB Entries (1)

P20425
KCY_DICDI
Dictyostelium discoideum
UMP-CMP kinase

PDB Structure

PDB 3UKD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative.
Schlichting, I., Reinstein, J.
Biochemistry