CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Bifunctional polynucleotide phosphatase/kinase

Enzyme Information

2.7.1.78
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt Q9JLV6
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
3.1.3.32
Polynucleotide 3'-phosphatase.
based on mapping to UniProt Q9JLV6
A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.

UniProtKB Entries (1)

Q9JLV6
PNKP_MOUSE
Mus musculus
Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB 3U7F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Coquelle, N., Havali-Shahriari, Z., Bernstein, N., Green, R., Glover, J.N.
Proc.Natl.Acad.Sci.USA