CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Beta-glucosidase 11

Enzyme Information

2.4.1.219
Vomilenine glucosyltransferase.
based on mapping to UniProt Q9SPP9
UDP-glucose + vomilenine = UDP + raucaffricine.
-!- The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions.
3.2.1.125
Raucaffricine beta-glucosidase.
based on mapping to UniProt Q9SPP9
Raucaffricine + H(2)O = D-glucose + vomilenine.
-!- Highly specific; some other ajmalan glucoside alkaloids are hydrolyzed, more slowly.

UniProtKB Entries (1)

Q9SPP9
RG1_RAUSE
Rauvolfia serpentina
Raucaffricine-O-beta-D-glucosidase

PDB Structure

PDB 3U57
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of alkaloid biosynthetic glucosidases decode substrate specificity.
Xia, L., Ruppert, M., Wang, M., Panjikar, S., Lin, H., Rajendran, C., Barleben, L., Stockigt, J.
Acs Chem.Biol.