CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Indole-3-glycerol phosphate synthase

Enzyme Information

4.1.1.48
Indole-3-glycerol-phosphate synthase.
based on mapping to UniProt P9WFX7
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

P9WFX7
TRPC_MYCTU
Mycobacterium tuberculosis H37Rv
Indole-3-glycerol phosphate synthase

PDB Structure

PDB 3T78
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights and Inhibition of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS): an Essential Enzyme for Tryptophan Biosynthesis
Reddy, M.C.M., Bruning, J.B., Thurman, C., Sacchettini, J.C.
To be Published