CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.360 | Malate synthase, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Malate synthase, domain 3 |
| Functional Family | Malate synthase G |
Enzyme Information
| 2.3.3.9 |
Malate synthase.
based on mapping to UniProt P9WK17
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.
|
UniProtKB Entries (1)
| P9WK17 |
MASZ_MYCTU
Mycobacterium tuberculosis H37Rv
Malate synthase G
|
PDB Structure
| PDB | 3SAD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol.
|